Research | HormoBiome

Investigación

En HORMOBIOME, nuestro objetivo es mejorar la salud global explorando una comprensión más profunda de la compleja interacción entre las hormonas y el microbioma. Llevamos a cabo investigaciones punteras en áreas críticas como la infertilidad, las enfermedades autoinmunes y el envejecimiento, con el objetivo de generar soluciones de impacto con base científica que beneficien a la sociedad.

Fertility

🔬 What We Study:
We explore how hormonal and microbiome imbalances in the reproductive and gastrointestinal tracts affect fertility in women with endometriosis. Our research focuses on identifying non-invasive biomarkers from the oral and gut microbiome to improve diagnosis and disease management.

🧪 Our Approach:
Using advanced metagenomics and metatranscriptomics, we analyze how hormonal imbalances shape microbial composition and how these interactions impact reproductive health. Our goal is to develop more precise and accessible diagnostic strategies for endometriosis-related infertility.

🎯 Why It Matters:
By understanding the microbiome-hormone connection, we aim to create non-invasive tools and personalized therapies to restore hormonal and microbial balance, optimizing fertility outcomes.

Menopause

🔬 What We Study:
Menopause is a critical stage in a woman’s life, marked by hormonal shifts and immune aging (immunosenescence), which impact the oral microbiome and overall health. The decline in estrogen levels and changes in salivary flow can lead to microbial imbalances and an increased risk of autoimmune diseases.

🧪 Our Approach:
We analyze microbial profiles in different oral habitats and their relationship with salivary estradiol levels to identify menopause-associated microbiome changes. Our research aims to uncover key microbial markers that could help in early detection and management of menopause-related health risks.

🎯 Why It Matters:
By understanding how hormonal and microbial shifts influence aging and immune health, we seek to develop preventive strategies that promote healthy aging and improve overall well-being in postmenopausal women.

Autoimmune Diseases

🔬 What We Study:
We investigate how hormones and microbiota influence the immune system in Sjögren’s syndrome (SS). Our goal is to understand how microbial changes contribute to disease progression and symptoms.

🧪 Our Approach:
We analyze bacteria and fungi in saliva from SS patients and healthy controls using advanced metagenomics and bioinformatics. By linking microbial communities to host immune factors, we aim to uncover new biomarkers and therapeutic targets.

🎯 Why It Matters:
By restoring hormonal and microbial balance, we hope to develop personalized treatments that improve immune function and patient outcomes.

Investigación

En HORMOBIOME, nuestro objetivo es mejorar la salud global explorando una comprensión más profunda de la compleja interacción entre las hormonas y el microbioma. Llevamos a cabo investigaciones punteras en áreas críticas como la infertilidad, las enfermedades autoinmunes y el envejecimiento, con el objetivo de generar soluciones de impacto con base científica que beneficien a la sociedad.

Oral Niche as Surrogate Biomarkers for Hormonal-Microbial Crosstalk in Endometriosis

The HORMOBIOME project explores how oral microbes interact with sex hormones, aiming to identify saliva-based biomarkers for endometriosis. This pioneering research connects oral health, microbiota, and women’s reproductive health to improve early diagnosis and treatment. Supported by the Spanish Ministry of Science and Innovation Grant ID PID2023-152369OB-I00.

Técnicas punteras

Para impulsar los avances en estas áreas de interés, HORMOBIOME emplea metodologías científicas punteras, proporcionando una visión completa de las interacciones hormona-microbioma.

Creamos sistemas de clasificación avanzados para las interacciones hormona-microbiota, organizados por etapas de la vida (p. ej., pubertad, embarazo, menopausia), tipos de hormonas y ubicaciones corporales (p. ej., intestino, piel, cavidad oral). Este marco ofrece a investigadores y clínicos una sólida herramienta para llevar a cabo investigaciones altamente personalizadas y desarrollar estrategias terapéuticas.

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Mapa de interacción hormonal-microbiana

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Multi-Omics Analysis

We utilize artificial intelligence and big data analytics to uncover complex patterns and predictive biomarkers in hormone-microbial interactions. This enables precision diagnostics and personalized therapies, leading to safer and more effective health outcomes.

AI-Driven Insights

La ciencia conectando hormonas, microbiota y salud

Investigación

Investigación

Técnicas punteras

HORMOBIOME LAB