Autoimmunity
What We Study
We investigate how hormonal fluctuations and imbalances shape immune-microbiome interactions and contribute to autoimmune disease trajectories, with a specific focus on conditions that predominantly affect women.
Autoimmune diseases are approached as hormone-sensitive systems, where endocrine dynamics influence microbial ecosystem stability, immune regulation and chronic inflammation.
Sjögren’s syndrome is studied as a highly informative disease model, given its strong female bias (9:1), hormonal sensitivity and mucosal manifestations, which make it particularly suitable for dissecting hormone–microbiome–immune interactions.
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Our Approach
Using integrative metagenomic, bioinformatic and immunological analyses, we characterize microbial community structure and function in non-invasive samples and relate these profiles to immune and clinical parameters. This framework allows us to identify shared patterns of dysbiosis, resilience loss and immune modulation associated with hormone-related autoimmunity.
Why It Matters
By framing autoimmunity as a dynamic, hormone-modulated process, rather than a static diagnosis, this research advances generalizable principles relevant to immune-mediated diseases in women. These insights support stratification approaches and hypothesis-driven translational research across autoimmune and inflammatory conditions.
